Surface Plasmon Resonance
For high-priority targets, where patent information, publications and proprietary data are insufficient to seed the evolutionary design algorithms, we apply a preliminary round of intelligent fragment screening, driven by Surface Plasmon Resonance (SPR) experiments.
The rapid application and high sensitivity of SPR avoids the delays often encountered with conventional assay development and permits fragment screening without the need for 3D structure.
In our hands the approach can be productively applied to both soluble targets and challenging, high-value G Protein Coupled Receptors (GPCRs). For GPCRs; Adenosine family, Beta2 Adrenoceptor, CXCR4, CCR5, S1P1, Histamine H1 are examples that have been successfully explored.